American stand-up comedian, writer and actor Patton Oswalt first began performing standup comedy in the late 1980s to early 1990s. After spending two seasons writing for MADtv, and starring in his own 1996 comedy special for HBO, he began performing in films and television shows.In January 2011, Oswalt released his first book, Zombie Spaceship Wasteland. Oswalt married writer Michelle Eileen McNamara on September 24, 2005. Their daughter, Alice Rigney Oswalt, was born on April 15, 2009.
| Movie | American Comic | Himself | 2025-06-29 |
| Movie | Absolute Dominion | 2025-05-09 | |
| Movie | Ghostbusters: Frozen Empire | Dr. Hubert Wartzki | 2024-03-20 |
| Movie | The Garfield Movie | (voice) | 2024-04-30 |
| Series | The 1% Club | Self - Host | 2024-06-03 |
| Movie | Unicorn Boy | King Uniturius (voice) | 2023-01-20 |
| Movie | 80 for Brady | Brisket | 2023-02-03 |
| Series | Shatter Belt | Dervey Ryan | 2023-11-05 |
| Movie | Heroes of the Golden Mask | Aesop (voice) | 2023-07-13 |
| Series | Mystery Science Theater 3000 | Max "Tv's Son of Tv's Frank" | 2022-05-06 |
| Movie | I Love My Dad | Chuck | 2022-08-05 |
| Movie | Weird: The Al Yankovic Story | Heckler | 2022-09-08 |
| Series | The Sandman | Matthew the Raven (voice) | 2022-08-05 |
| Movie | Minions & More Volume 2 | Max (voice) | 2022-11-08 |
| Movie | The Sparks Brothers | Self | 2021-06-18 |
| Series | Marvel's M.O.D.O.K. | George Tarleton / M.O.D.O.K. (voice) | 2021-05-21 |
| Movie | The Spine of Night | Pyrantin (voice) | 2021-10-29 |
| Movie | Eternals | Pip the Troll (voice) | 2021-11-03 |
| Movie | Reno 911!: The Hunt for QAnon | Ron | 2021-12-23 |
| Movie | The Super Bob Einstein Movie | Self | 2021-12-28 |
| Movie | We Bare Bears: The Movie | Nom Nom (voice) | 2020-06-30 |
| Series | Home Movie: The Princess Bride | Vizzini | 2020-06-29 |
| Movie | Best of Stand-up 2020 | Self | 2020-12-31 |
| Movie | For Madmen Only: The Stories of Del Close | Lash LaRue | 2020-10-14 |
| Movie | Kim Possible | Professor Dementor | 2019-02-15 |
| Movie | The Secret Life of Pets 2 | Max (voice) | 2019-05-24 |
| Movie | We Brought Back MST3K | Self | 2018-04-17 |
| Movie | Nostalgia | Kathleen's Father | 2018-02-16 |
| Series | A.P. Bio | Principal Ralph Durbin | 2018-02-01 |
| Series | Spy Kids: Mission Critical | 2018-04-20 | |
| Movie | Please Stand By | Officer Frank | 2018-01-26 |
| Movie | Sex Madness Revealed | Jimmy Morris | 2018-04-20 |
| Movie | Teen Titans Go! To the Movies | Atom (voice) | 2018-07-27 |
| Series | Minecraft: Story Mode | Jesse (male voice) | 2018-11-27 |
| Movie | Sorry to Bother You | Mr. _______'s White Voice (voice) | 2018-07-06 |
| Movie | The Circle | Tom Stenton | 2017-04-27 |
| Movie | Gilbert | Self | 2017-04-20 |
| Series | Mystery Science Theater 3000 | Max (TV's Son of TV's Frank) | 2017-04-14 |
| Series | The History of Comedy | Self | 2017-02-09 |
| Series | Marvel's Spider-Man | Uncle Ben (voice) | 2017-08-19 |
| Series | I Love You, America | Himself | 2017-10-12 |
| Movie | Click, Clack, Moo: Christmas at the Farm | Appliance Al (voice) | 2017-11-28 |
| Series | HAPPY! | Happy (voice) | 2017-12-06 |
| Movie | Patton Oswalt: Annihilation | Self | 2017-10-17 |
| Movie | Patton Oswalt: Talking for Clapping | Self | 2016-04-22 |
| Movie | The Confirmation | Drake | 2016-03-18 |
| Movie | Donald Trump's The Art of the Deal: The Movie | Merv Griffin | 2016-02-10 |
| Series | Lady Dynamite | Patton Cop | 2016-05-20 |
| Movie | Keeping Up with the Joneses | Bruce Springstein / Scorpion | 2016-10-20 |
| Movie | Neil Gaiman: Dream Dangerously | Self | 2016-07-08 |
| Movie | Zoolander: Super Model | Dr. Botoxo (voice) | 2016-08-01 |
| Movie | Nerdland | Elliot (voice) | 2016-12-06 |
| Series | HarmonQuest | 2016-07-14 | |
| Movie | Chronic-Con, Episode 420: A New Dope | Self | 2015-07-03 |
| Movie | Dude Bro Party Massacre III | Chief | 2015-06-13 |
| Movie | Mune: Guardian of the Moon | Mox (voice) | 2015-02-05 |
| Series | Difficult People | Kenny Jurgens | 2015-08-05 |
| Movie | Call Me Lucky | Self | 2015-08-07 |
| Movie | Freaks of Nature | Stuart Miller | 2015-10-30 |
| Movie | Welcome to Bridgetown | Self | 2015-09-01 |
| Series | We Bare Bears | Nom Nom (voice) | 2015-08-24 |
| Movie | The Loneliest Stoplight | Narrator (voice) | 2015-08-21 |
| Movie | Jason Nash Is Married | Producer | 2014-06-24 |
| Movie | Harmontown | Self | 2014-03-08 |
| Movie | Patton Oswalt: Tragedy Plus Comedy Equals Time | Self | 2014-01-17 |
| Series | BoJack Horseman | Pinky Penguin (voice) | 2014-08-22 |
| Series | The Tonight Show Starring Jimmy Fallon | Himself | 2014-02-17 |
| Movie | 22 Jump Street | MC State History Professor (uncredited) | 2014-06-05 |
| Movie | Out of Print | Self | 2014-08-23 |
| Movie | Marvel: 75 Years, from Pulp to Pop! | Self | 2014-11-04 |
| Movie | Sex and Broadcasting | Self | 2014-11-15 |
| Movie | Lemonade War | Jerry | 2014-09-30 |
| Movie | We the Economy: 20 Short Films You Can't Afford to Miss | Lemonade Stand Dad | 2014-10-21 |
| Series | Brooklyn Nine-Nine | Fire Marshall Boone | 2013-09-17 |
| Movie | Odd Thomas | Ozzie P. Boone | 2013-01-29 |
| Series | The Goldbergs | Adam Goldberg (voice) | 2013-09-24 |
| Series | Orphan Black | Himself | 2013-03-30 |
| Series | Drunk History | Mac Brazel | 2013-07-09 |
| Series | Marvel's Agents of S.H.I.E.L.D. | Eric Koenig, Billy Koenig, Sam Koenig | 2013-09-24 |
| Movie | Radiolab Live: Apocalyptical | Self | 2013-12-09 |
| Movie | The Secret Life of Walter Mitty | Todd Maher | 2013-12-18 |
| Movie | The Walking Dead: A Decade of Dead | Self | 2013-10-11 |
| Movie | Nature Calls | Randy Stevens | 2012-03-10 |
| Movie | WordGirl: The Rise of Ms. Power | 2012-01-01 | |
| Series | Gravity Falls | Franz (voice) | 2012-06-15 |
| Movie | The Bitter Buddha | Self | 2012-06-15 |
| Movie | Seeking a Friend for the End of the World | Roache | 2012-06-22 |
| Movie | Viva Lucha Libre | Self | 2012-09-14 |
| Movie | A Very Harold & Kumar Christmas | Mall Santa | 2011-11-04 |
| Movie | Patton Oswalt: Finest Hour | Self | 2011-09-05 |
| Movie | Warren Ellis: Captured Ghosts | Self | 2011-11-01 |
| Movie | Who the F#ck Is Chip Seinfeld? | Self | 2011-11-11 |
| Series | The Heart, She Holler | Hurlan | 2011-11-06 |
| Series | Billy on the Street | Himself | 2011-12-18 |
| Movie | Young Adult | Matt Freehauf | 2011-11-11 |
| Series | Caprica | Baxter Sarno | 2010-01-22 |
| Movie | Fantasia in Best Show Minor | 2010-01-01 | |
| Movie | Blood Into Wine | Self | 2010-02-19 |
| Series | Justified | Constable Bob Sweeney | 2010-03-16 |
| Series | Neighbors from Hell | Pazuzu | 2010-06-07 |
| Movie | Beautiful Darling | Andy Warhol (voice) / Truman Capote (voice) | 2010-04-02 |
| Series | Robotomy | 2010-10-25 | |
| Movie | Weird: The Al Yankovic Story | Dr. Demento | 2010-03-22 |
| Series | Parks and Recreation | Garth Blundin | 2009-04-09 |
| Series | Dollhouse | Unknown | 2009-02-13 |
| Series | United States of Tara | Unknown | 2009-01-18 |
| Movie | Observe and Report | Toast A Bun Manager | 2009-04-10 |
| Movie | Big Fan | Paul Aufiero | 2009-02-07 |
| Movie | The Informant! | Ed Herbst | 2009-09-18 |
| Series | Community | Male Nurse Jackie | 2009-09-17 |
| Movie | Al's Brain | Co-Worker | 2009-07-10 |
| Movie | Patton Oswalt: My Weakness Is Strong | Self | 2009-08-25 |
| Movie | Funny People: Live | Self | 2009-07-24 |
| Movie | All Roads Lead Home | Milo | 2008-01-01 |
| Movie | Largo | Self | 2008-02-01 |
| Series | Lewis Black's Root of All Evil | Unknown | 2008-03-12 |
| Movie | History of the Joke | Self | 2008-02-28 |
| Movie | Ratatouille | Remy (voice) | 2007-06-28 |
| Movie | Patton Oswalt: Werewolves and Lollipops | Self | 2007-07-10 |
| Series | Flight of the Conchords | Unknown | 2007-06-17 |
| Movie | The Sophisticated Misfit | Self | 2007-04-26 |
| Movie | Reno 911!: Miami | Jeff Spoder | 2007-02-23 |
| Series | Human Giant | Unknown | 2007-04-05 |
| Movie | Sex and Death 101 | Fred | 2007-06-15 |
| Movie | Comedy Central Roast of Flavor Flav | Self | 2007-08-12 |
| Movie | Super High Me | Self | 2007-10-13 |
| Movie | Heckler | Self | 2007-11-04 |
| Movie | Your Friend the Rat | Remy (voice) | 2007-11-06 |
| Movie | Wrong Turn 2: Dead End | Tommy (voice) | 2007-08-25 |
| Series | Reaper | Unknown | 2007-09-25 |
| Movie | The Comedians of Comedy: Live at The Troubadour | Self | 2007-09-18 |
| Movie | Balls of Fury | Hammer | 2007-08-29 |
| Series | WordGirl | Unknown | 2007-09-07 |
| Movie | Failure to Launch | Techie Guy | 2006-03-10 |
| Movie | The Comedians of Comedy: Live at the El Rey | Self | 2006-01-01 |
| Series | Live at Gotham | Unknown | 2006-07-21 |
| Series | Amazing Screw-On Head | 2006-07-27 | |
| Movie | Comedy Central Roast of William Shatner | Self - Roaster | 2006-08-20 |
| Movie | The Amazing Screw-On Head | Mr. Groin (voice) | 2006-08-20 |
| Series | American Dad! | Unknown | 2005-02-06 |
| Movie | The Comedians of Comedy | Self | 2005-03-01 |
| Movie | Cake Boy | Cake Pervert | 2005-06-21 |
| Series | Comedians of Comedy | Self | 2005-11-11 |
| Movie | Last Laugh '05 | Self | 2005-12-11 |
| Series | Too Late with Adam Carolla | Unknown | 2005-08-08 |
| Movie | Starsky & Hutch | Disco DJ | 2004-03-05 |
| Movie | See This Movie | Felix | 2004-03-03 |
| Series | Best Week Ever | 2004-01-23 | |
| Series | The Venture Bros. | Unknown | 2004-08-07 |
| Series | Tom Goes to the Mayor | 2004-11-14 | |
| Series | The Batman | Unknown | 2004-09-11 |
| Movie | Patton Oswalt: No Reason to Complain | Self | 2004-12-05 |
| Movie | Blade: Trinity | Hedges | 2004-12-08 |
| Movie | Taxi | Clerk at Inpound Office | 2004-10-06 |
| Series | Jimmy Kimmel Live! | Unknown | 2003-01-26 |
| Series | Reno 911! | 2003-07-23 | |
| Series | Two and a Half Men | Billy Stanhope | 2003-09-22 |
| Movie | Calendar Girls | Larry | 2003-09-02 |
| Movie | Run Ronnie Run | Dozer - Editor #1 | 2002-01-20 |
| Movie | Zig Zag | Shelly | 2002-06-14 |
| Series | Kim Possible | Unknown | 2002-06-07 |
| Movie | Zoolander | Monkey Photographer | 2001-09-28 |
| Movie | Desperate But Not Serious | Auteur #1 | 2000-10-31 |
| Series | Static Shock | Unknown | 2000-09-23 |
| Series | Aqua Teen Hunger Force | Unknown | 2000-12-30 |
| Series | Batman Beyond | Unknown | 1999-01-10 |
| Series | Home Movies | Unknown | 1999-04-26 |
| Movie | Magnolia | Delmer Darion | 1999-12-17 |
| Movie | Man on the Moon | Blue Collar Guy | 1999-12-22 |
| Series | The King of Queens | Spence Olchin | 1998-09-21 |
| Series | Comedy Central Presents | Unknown | 1998-12-01 |
| Series | Emeril Live | 1997-01-01 | |
| Series | The Weird Al Show | Unknown | 1997-09-13 |
| Movie | Down Periscope | Stingray Radioman | 1996-03-01 |
| Series | The Daily Show | Unknown | 1996-07-22 |
| Series | NewsRadio | Unknown | 1995-03-21 |
| Series | MADtv | Unknown | 1995-10-14 |
| Series | Dr. Katz, Professional Therapist | Unknown | 1995-05-28 |
| Series | Late Night with Conan O'Brien | Unknown | 1993-09-13 |
| Series | The Tonight Show with Jay Leno | Unknown | 1992-05-25 |
| Series | Seinfeld | Unknown | 1989-07-05 |
| Series | Mystery Science Theater 3000 | Max / TV's Son of TV's Frank | 1989-11-25 |