Born in Madrid, Santiago Segura started his career by making his first short movie at the age of fourteen. After studying Arts in Madrid, he finally decided to become a filmmaker. His first short film Relatos de la medianoche (1989) was made with a budget of only 7.000 pts. (about 60 dollars). After that, he appeared as a contestant in several Spanish TV quiz shows, such as Locos por la tele (1990) and No te rías, que es peor (1990). With the money he made of those appareances, he directed Evilio. (1992) and shortly after, Perturbado (1993), winning a Goya for the best short film in 1994. His last short film is the sequel Evilio vuelve (El purificador) (1994). He's a very good friend of the Spanish director Álex de la Iglesia and he has appeared in all of his films. In 1998, he directed his firt feature film, the smashing hit Torrente, el brazo tonto de la ley (1998).
| Movie | She Rides Shotgun | Luis | 2025-07-31 |
| Movie | A nadie le importas | 2025-03-15 | |
| Movie | Father There is Only One 4 | Javier García | 2024-07-17 |
| Movie | The Stratum | Ramone | 2023-03-07 |
| Movie | Summer Vacation | Félix | 2023-07-06 |
| Movie | The Night My Dad Saved Christmas | Papá Noel | 2023-12-01 |
| Movie | The Portrait | Deputy Alvarez | 2023-10-20 |
| Movie | Padre no hay más que uno 3 | Javier García | 2022-07-15 |
| Movie | The Kids Are Alright 2 | Ricardo | 2022-12-02 |
| Movie | Las Parcas | Hades | 2021-01-01 |
| Series | LOL - Last One Laughing Spain | Self - Host | 2021-05-14 |
| Series | El desafío | Self - Jury Member | 2021-01-15 |
| Movie | Berlanga!! | Self - Filmmaker | 2021-10-26 |
| Movie | The Kids Are Alright: Destination Asturias | Ricardo | 2021-07-08 |
| Movie | La suite nupcial | Arturo | 2020-01-10 |
| Movie | Father There Is Only One 2 | Javier García | 2020-07-29 |
| Movie | The Five Rules Of Success | X | 2020-08-24 |
| Movie | Ibáñez | Self - Filmmaker | 2020-12-20 |
| Movie | El Roast de José Mota | Himself | 2019-02-24 |
| Movie | Yo soy Arturo Fernández | Himself - Filmmaker | 2019-07-07 |
| Movie | 31-D: Un golpe de gracia | 2019-12-31 | |
| Movie | Father There Is Only One | Javier García | 2019-08-02 |
| Movie | The Rodriguez and the Beyond | Rugen Zelig | 2019-10-31 |
| Movie | Dark Buildings (A Crack in the Wall) | Mario Borla | 2018-01-18 |
| Movie | Empowered | Amil Narayan | 2018-03-02 |
| Movie | 47 Meters Down | Benjamin | 2017-05-25 |
| Movie | Casi leyendas | Axel | 2017-03-16 |
| Movie | You Only Live Once | Tobías López | 2017-06-15 |
| Movie | Los resucitados | 2017-10-07 | |
| Movie | His Double Life | August | 2016-06-05 |
| Movie | Wild Oats | Carlos | 2016-09-22 |
| Series | El hombre de tu vida | Unknown | 2016-05-26 |
| Movie | Heirs of the Beast | 2016-10-10 | |
| Movie | The Queen of Spain | Castillo | 2016-11-25 |
| Movie | Possessed | Damián / Bishop / Satan (voice) | 2015-04-30 |
| Series | Scream: The TV Series | Gustavo Acosta | 2015-06-30 |
| Movie | My Big Night | Benítez | 2015-10-23 |
| Movie | Delirium | Billy | 2014-06-20 |
| Movie | El culo del mundo | 2014-04-11 | |
| Series | Tu cara me suena mini | Self - Contestant | 2014-09-11 |
| Series | Faking It | Sam | 2014-04-22 |
| Movie | Torrente 5 | José Luis Torrente | 2014-10-03 |
| Movie | Un País de Cuento | 2014-12-31 | |
| Movie | Gala 15 Aniversario Stage Entertainment | 2014-12-28 | |
| Movie | Pacific Rim | Wizened Man | 2013-07-11 |
| Movie | Witching & Bitching | Miren | 2013-09-20 |
| Series | Splash! Famosos al agua | Self - Jury Member | 2013-03-04 |
| Series | Torres y Reyes | 2013-09-26 | |
| Movie | People in Places | 2013-12-20 | |
| Series | Me resbala | 2013-11-15 | |
| Movie | Le Chef | Juan | 2012-03-07 |
| Series | Fenómenos | Líder de la secta | 2012-11-27 |
| Movie | Torrente 4: Lethal crisis | José Luis Torrente | 2011-03-11 |
| Series | Tu cara me suena | Himself - Artista invitado | 2011-09-28 |
| Movie | As Luck Would Have It | David Solar | 2011-11-30 |
| Movie | Jack and Jill | Eduardo (uncredited) | 2011-11-11 |
| Movie | The Great Vazquez | Manuel Vázquez | 2010-09-24 |
| Movie | Unresolved Sexual Tension | Pedro el Hacker | 2010-03-18 |
| Movie | ¿Por qué te vas? | Priest | 2010-11-05 |
| Movie | The Last Circus | Padre-Payaso tonto | 2010-12-17 |
| Series | La Hora de José Mota | Unknown | 2009-01-16 |
| Movie | Hellboy II: The Golden Army | Distinguished Buyer | 2008-07-11 |
| Movie | Asterix at the Olympic Games | Doktormabus | 2008-01-25 |
| Movie | A Matador's Mistress | Guillermo | 2008-09-06 |
| Movie | Ekipo Ja | Santiago Segura | 2007-01-19 |
| Series | Sabias a lo que venías | Self | 2007-04-10 |
| Movie | Bienvenido a casa | 2006-04-07 | |
| Movie | La máquina de bailar | Johnny | 2006-09-22 |
| Movie | Isi & Disi: alto voltaje | Isi | 2006-12-01 |
| Series | El hormiguero | Colaborador | 2006-09-24 |
| Movie | Torrente 3: The Protector | José Luis Torrente | 2005-09-30 |
| Movie | Agent Cody Banks 2: Destination London | Santiago | 2004-03-12 |
| Movie | Say I Do | Oscar Vásquez | 2004-01-13 |
| Movie | Hellboy | Train Driver | 2004-04-02 |
| Movie | Promedio rojo | Doctor | 2004-11-04 |
| Movie | Isi/Disi - Amor a lo bestia | Isi | 2004-07-23 |
| Movie | El asombroso mundo de Borjamari y Pocholo | Borjamari | 2004-12-03 |
| Movie | Moscow Gold | Íñigo Fuentes | 2003-03-28 |
| Movie | Comandante | Self (uncredited) | 2003-02-14 |
| Movie | Beyond Re-Animator | Speedball | 2003-04-04 |
| Movie | Una de zombis | Padre Pelayo / Entrecot / Himself | 2003-11-29 |
| Movie | Blade II | Rush | 2002-03-22 |
| Movie | Zero/infinito | (voice) | 2002-01-01 |
| Movie | Tiptoes | Motel Manager | 2002-12-17 |
| Movie | I Murder Seriously | Padre Gorkisolo | 2002-10-11 |
| Movie | El sueño de la maestra | Morales | 2002-12-20 |
| Movie | Torrente 2: Mission in Marbella | José Luis Torrente | 2001-03-30 |
| Movie | Manolito Four Eyes: The Mischievous Holidays | Himself (uncredited) | 2001-06-22 |
| Movie | Chica de Río | Paulo | 2001-06-29 |
| Movie | Heart of the Warrior | Netheril / Carlos José | 2000-01-21 |
| Movie | Pídele cuentas al rey | Vagabundo | 2000-02-10 |
| Movie | Obra maestra | Benito Cañaveras | 2000-10-27 |
| Movie | Sabotage!! | Cyrille Léotard | 2000-10-14 |
| Movie | Dying of Laughter | Nino | 1999-03-12 |
| Movie | París-Tombuctú | Cura | 1999-09-10 |
| Movie | The Ugliest Woman in the World | El presidente de la República (uncredited) | 1999-11-05 |
| Series | El Club de la Comedia | Monologuista | 1999-09-26 |
| Movie | Torrente, the Dumb Arm of the Law | José Luis Torrente | 1998-03-13 |
| Movie | The Girl of Your Dreams | Castillo | 1998-11-13 |
| Movie | Airbag | Candidato Paiño | 1997-06-20 |
| Movie | Jistory: Santiago Segura Corto Greatest Jits | 1997-06-06 | |
| Movie | Dance with the Devil | Shorty Dee | 1997-10-31 |
| Movie | Matías, juez de línea | Antidisturbios | 1996-04-12 |
| Movie | Sólo se muere dos veces | Amilibia | 1996-03-10 |
| Movie | Vampire Killer Barbys | Baltasar | 1996-05-22 |
| Movie | Tengo una casa | Guardia 1 | 1996-09-13 |
| Movie | The Good Life | 1996-12-13 | |
| Movie | Cuernos de mujer | Ciego | 1995-04-07 |
| Movie | The Day of the Beast | José María | 1995-10-20 |
| Movie | Two Much | Paparazzi | 1995-12-01 |
| Movie | Todo es mentira | Vendedor | 1994-10-14 |
| Movie | Mutant Action | Ezequiel | 1993-02-03 |
| Movie | Disturbed | 1993-03-01 | |
| Movie | Everyone Off to Jail | Ecologista | 1993-12-22 |
| Movie | Evilio | Evilio | 1992-01-01 |
| Movie | High Heels | (uncredited) | 1991-10-23 |